| WP | | WP Leader | Delegate (WPL) | Support (WPVL) |
| 1 | Management and coordination | UGent | Patrick Segers | Soroush Safaei |
| 2 | Multi-scale multi-organ model development | UOA | Peter Hunter | Bart Spronck |
| 3 | Sensing biomarkers for dynamic personalisation of virtual human twins | IMEC-NL | Fabian Beutel | post-doc EPFL |
| 4 | Virtual human twin and model personalisation | TU Delft | Mathias Peirlinck | Mariano Vazquez |
| 5 | Clinical studies | APHP | Rosa Maria Bruno | Gabriella Captur |
| 6 | Patient-Physician-Digital health technology interactions | UNIPI | Martina Smorti | Jordi Alastruey |
| 7 | Valorisation and exploitation in EU’s virtual human twin ecosystem | AIT | Bernhard Hametner | Berend Westerhof |
| 8 | Networking, training, communication and dissemination | UCL | Chloe Park | Finbar Argus |
| 9 | Ethics requirements | UGent | Patrick Segers | Alun Hughes |
