WP2

Lead: University of Auckland

Objectives

1: Create computational models that integrate neuro, mechanical, and drug modulation to simulate cardiac function at multiple scales. These models will be used to gain a better understanding of the underlying mechanisms of cardiac disease and to identify new therapeutic targets.
2: Develop multi-scale models of the arterial and venous systems that incorporate the effects of the autonomic nervous system on vascular function. These models will be used to investigate the mechanisms underlying hypertension, atherosclerosis, and other vascular diseases, as well as to identify new therapeutic targets.
3: Develop models of the autonomic nervous system that capture its complex interactions with the cardiovascular, renal, and endocrine systems. These models will be used to explore the effects of autonomic dysfunction on health and disease, and to develop new strategies for treating conditions such as hypertension, heart failure, and diabetes.
4: Integration of existing and developed (0D, 1D, and 3D) codes in one computationally efficient, modular framework to enable researchers to easily combine different models and simulations to gain new insights into complex physiological systems